Steiner, MD Neonates with profound and prolonged hyperammonemia with coma due to urea cycle defect will have ... ornithine transcarbamylase deficiency; PCD, pyruvate carboxylase deficiency ...

This enzyme links the two stages of cellular respiration: glycolysis and the citric acid cycle. In doing so, pyruvate dehydrogenase helps regulate the metabolic plasticity of cells. The ...

Higher MPC expression resulted in smaller cells, not by increasing TCA cycle flux as observed in other cell types, but instead by redirecting mitochondrial pyruvate metabolism towards gluconeogenesis.

This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

2 4 A few cases have been reported that involve deficiencies in enzymes of the tricarboxylic acid cycle, such as fumarase, or of gluconeogenesis, such as pyruvate carboxylase (PC) or ...

Resistance evolution in response to stimulatory antibiotics is driven by epigenetic modifications and mutations in metabolic ...

Centre for Engineering Biology, Institute of Quantitative Biology, Biochemistry and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FF, U.K. Centre for ...

The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock's most recent closing price by the sum of the diluted earnings per share from continuing operations ...

Knowing the risks of each cycle equips you to avoid them. In the accumulation phase, the market has bottomed, and early adopters and contrarians see an opportunity to scoop up bargains.