As shown in Figure 4, the odds of vortioxetine treated patients achieving a ≥50% MADRS score reduction from baseline was about 3 times higher than placebo treated patients (Overall OR = 2.87 ...

BNA™ Metrics as Cognitive Biomarkers: Baseline brain activation latencies, as measured through Firefly's BNA™ technology, ...

Takeda Pharmaceuticals and Lundbeck have jointly announced the submission of a New Drug Application (NDA) to the US FDA for the investigational agent vortioxetine. Vortioxetine (Lu AA21004 ...

The second paper, entitled "Evaluating an EEG-based tool for assessing acute clinical and cognitive changes in adult outpatients with MDD treated with open-label, flexible-dose vortioxetine ...

This article was reviewed by Daniel Z. Lieberman, MD If you’ve been diagnosed with major depressive disorder, seasonal affective depression or any other type of depression, your healthcare ...

The company is also facing patent expiries for its antidepressant Trintellix/Brintellix (vortioxetine) – for many years its biggest-selling drug – in 2026, while its new top product Rexulti ...

If you’ve been diagnosed with major depressive disorder, seasonal affective depression or any other type of depression, your healthcare provider might prescribe an antidepressant to control your ...

Venlafaxine prescribing information. Shin C, Jeon SW, Lee SH, et al. Efficacy and Safety of Escitalopram, Desvenlafaxine, and Vortioxetine in the Acute Treatment of Anxious Depression: A Randomized ...

While select antidepressants, e.g., vortioxetine, have been demonstrated to have direct and independent pro-cognitive effects in adults with MDD, research on additional agents remains nascent. A ...

Methods: Adults meeting the DSM-5 criteria for MDD with at least moderate depressive symptom severity [i.e., Montgomery Åsberg Depression Rating Scale (MADRS) total score ≥ 20] were treated with ...

Withdrawal symptoms can vary depending on the antidepressant, and strategies for tapering off the medication may help.