This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering ...

Comparative genomics deals with the processes of evolution via the alignment and analysis of genes and genomes of living or extinct organisms related by varying degrees of evolutionary divergence ...

Genomics is the study of the full genetic complement of an organism (the genome). It employs recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyse the ...

An oligodendrocyte-specific genomic silencer element determines the cell type specificity for a fatal neurological disorder caused by a widely expressed nuclear protein (Lamin B1) and suggests a ...

Working with a diverse panel of rice accessions grown in field conditions, this valuable study measures changes in transcript abundance, tests for patterns of selection on gene expression, and maps ...

Dr. Yipu Zhang, Assistant Professor at the School of Medicine, Department of Biomedical Informatics and Genomics, indicates that multi-site clinical imaging data is prone to systematic biases, sub-par ...

Technological advances have reduced genome sequencing costs to $600, boosting growth in the genomics sector. The genetic testing market is forecast to hit $91.3 billion by 2034, enhancing disease ...

“Our goal was to try to predict the three-dimensional genome structure from the underlying DNA sequence,” says Bin Zhang, an associate professor of chemistry and the senior author of the study. “Now ...

Species concepts have long provided a source of debate among biologists. These lively debates have been important for reaching consensus on how to communicate across scientific disciplines and for ...

Multidrug resistance (MDR) of tumors is one of the clinical direct reasons for chemotherapy failure. MDR directly leads to tumor recurrence and metastasis, with extremely grievous mortality.

2020). Genome browser images were created using the Integrative Genomics Viewer (IGV) v2.8.10 (Thorvaldsdóttir et al., 2013) and bigwig files were processed as described above. Taken together, our ...