The Stayers' Hurdle is the feature race of Day Three at the Cheltenham Festival with Gordon Elliott's Teahupoo bidding to ...

We found that the three DNA-damaging drugs, namely Nutlin, Doxorubicin, and 5-Fluorouracil (5-FU), stabilized p53 and concurrently repressed BLM and RAD51 in both HCT116 WT and HCT116 p21−/− cells but ...

Researchers at the Garvan Institute of Medical Research have uncovered how pancreatic cancer hijacks a crucial metabolic ...

While the study provides preliminary evidence that inhibiting NPY may reduce cancer spread and reduce weight loss ... NPY/NPY1R Signaling Axis in Mutant p53-Dependent Pancreatic Cancer Impairs ...

5-FU (Sigma, F6627-1G) was dissolved in DMSO (Sigma, D2650-100ML) as a stock solution at 375 mM. HCT116 WT and HCT116 p53 KO cells (with or without Ad-p53 infection) were treated with 375 μM 5-FU for ...

The extracted proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) based on their molecular weight. After separation ... signaling pathway, the p53 signaling ...