Lipid nanoparticle platform delivers mRNA to the brain
New lipid nanoparticle platform delivers mRNA to the brain through the blood-brain barrier
Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier.
This important study examines the role of pericytes in patterning the zebrafish blood-brain barrier (BBB) and controlling its permeability. Using pdgfrb mutant zebrafish models lacking brain pericytes ...
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Method to measure blood-brain barrier permeability accurately developedFor decades, scientists across the globe have investigated methods to accurately measure drug permeability across the ...
The delivery challenge is posed by the blood–brain barrier (BBB), which prevents around ... and retain the ability to traverse the BBB (Fig. 1). Published in vitro and in vivo studies by NEUWAY ...
The blood–brain barrier ... for crossing this barrier. The upper limit of pore size in the BBB that enables passive flow of molecules across it is usually <1 nm; however, particles that have ...
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