This important study examines the role of pericytes in patterning the zebrafish blood-brain barrier (BBB) and controlling its permeability. Using pdgfrb mutant zebrafish models lacking brain pericytes ...

For decades, scientists across the globe have investigated methods to accurately measure drug permeability across the ...

The delivery challenge is posed by the blood–brain barrier (BBB), which prevents around ... and retain the ability to traverse the BBB (Fig. 1). Published in vitro and in vivo studies by NEUWAY ...

Scientists at the Icahn School of Medicine at Mount Sinai have developed a lipid nanoparticle system capable of delivering ...

The blood–brain barrier ... for crossing this barrier. The upper limit of pore size in the BBB that enables passive flow of molecules across it is usually <1 nm; however, particles that have ...

Scientists at the Icahn School of Medicine at Mount Sinai have developed a lipid nanoparticle system capable of delivering ...

ABL Bio’s first-in-class bispecific antibodies for Parkinson’s disease combine unprecedented blood–brain barrier penetration ... The product is entering a phase 1 trial, a first for a ...