The bruised and battered San Francisco 49ers will need these five players to step up against the short-handed Los Angeles ...

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve on Aug. 14 but have yet to fill his vacant ...

According to Tallysight, a whopping 96% of experts are picking the 49ers to beat the Rams. It’s slightly better when ...

Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and ...

The San Francisco 49ers will face the Los Angeles Rams on Sunday without wide receiver Deebo Samuel and running back ...

Herbert injured his right leg in the third quarter of Week 2’s 26-3 win against the Carolina Panthers trying to escape the ...

Injuries have caused many problems for the San Francisco 49ers this year, and now Brock Purdy has lost another offensive ...

Week 3 matchup vs. Rams with key injuries to McCaffrey, Samuel, and Kittle, testing their depth in this crucial NFC West ...

The San Francisco 49ers could be without another key offensive player this week after All-Pro tight end George Kittle missed ...

One game down, three more to go until Christian McCaffrey is eligible to come off Injured Reserve. The San Francisco 49ers placed McCaffrey on I.R. on Sept. 14 ...

An oblique injury has kept Seattle Seahawks running back Kenneth Walker III out of the lineup. He missed their Week 2 win ...