Acute promyelocytic leukemia was once the 'worst of the worst' among hematologic malignancies, but it can now be treated without chemotherapy.

The chemotherapy-free combination of arsenic trioxide and all-trans retinoic acid significantly improved event-free survival with less toxicity and lower cost than standard chemotherapy.

For example, grade 1-4 thrombocytopenia persisting for more than 15 days occurred in 15% of patients compared with 22% of patients in the ATRA-chemotherapy arm during induction, Platzbecker ...

This trial is looking at having ATRA with gemcitabine and nab-paclitaxel chemotherapy for pancreatic cancer..

When maintenance chemotherapy has been combined with ATRA, or ATRA given alone in two randomised trials there was a superior disease-free and overall survival. 4, 6 However, a recently updated ...

The combination regimen of chemotherapy and ATRA dramatically improved the survival outlook for those with APL and made the disease curable in up to 80 percent of patients.

At present, ATRA combined with chemotherapy became the classic treatment of APL owing to the significantly improved long-term survival rate.

The consensus price target hints at a 33% upside potential for Atara Biotherapeutics (ATRA). While empirical research shows that this sought-after metric is hardly effective, an upward trend in ...

A new study examined the combination of the common immunotherapy drug pembrolizumab (Keytruda) with all-trans retinoic acid (ATRA), a chemotherapy drug that targets myeloid-derived suppressor ...

Discussion Combination ATRA and anthracycline-based chemotherapy (ABCT) is the currently recognized standard for the induction and consolidation therapy of newly diagnosed APL, 25 with induction death ...

A randomized clinical trial compared efficacy and toxicity of standard all- trans -retinoic acid (ATRA) plus chemotherapy versus ATRA plus arsenic trioxide in patients with newly diagnosed, low- or ...