Here we report an in-depth analysis of the catalytic features ... phosphorylation activity of the kinase along with its ability to phosphorylate S32/S36 of IκBα, thereby clearly suggesting a critical ...

Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single ...

Commissions do not affect our editors' opinions or evaluations. A custom domain name is your address on the internet. It makes up part of the URL shown at the top of your browser window and lets ...

An example of where these differences matter come from comparing X-ray cocrystal structures derived from either soaking or cocrystallizing of the drug AZD9291 (osimertinib) bound to the epidermal ...

Phosphorylation of NKCC1 N-terminal domain (NTD) residues Thr212, Thr217, and Thr230 fosters associations between NTD and C-terminal domain (CTD) and between cytosolic domains and the transmembrane ...

The authors note that Constanza Torres-Paris should be added to the author list between Steve Silletti and Junru Hu. Constanza Torres-Paris should be credited with designing research, performing ...

A major group of enzymes that influence epigenetic modifications are lysine demethylases (KDMs ... initially identified in a study targeting genes regulated by the tyrosine kinase HER2 (Lu et al., ...

Figure 2 Organization of human IRAK proteins. IRAK proteins contain a death domain (DD), ProST domain, kinase domain (inactive in IRAK-M) and a C-terminal domain (absent in IRAK4). IRAK1 has two ...

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One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...