An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

A new study has uncovered a surprising link between Alzheimer’s disease and Herpes Simplex Virus-1 (HSV-1). Researchers found ...

These efforts are being extended to CRISPR-transposition systems and to provide an understanding of recognition principles involving evolved viral suppressor proteins that inhibit the CRISPR-Cas ...

Another significant area of research is the cGAS-STING pathway, which is activated in response to cytosolic DNA. This pathway has been implicated in various inflammatory conditions, including SLE.

“This led us to explore a specific immune response pathway in the brain, the cGAS-STING pathway,” he detailed. “We found that molecules of this pathway are present where HSV-1 and modified ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

This protective effect worked through the cGAS-STING-TBK1 immune pathway. The research primarily used postmortem brain tissue and laboratory models, which may not fully reflect the complexity of ...

His contributions to the cGAS-cGAMP-STING pathway unveiled the intricate mechanisms in response ... Experts from the Women’s Brain Foundation and bit.bio will explore the importance of sex-specific in ...