Cigarette smoke causes cancer primarily by damaging the DNA. A new study that mapped these damages has revealed that the way ...

Genetic instability can arise as a function of hypoxia-mediated resistance to apoptosis and decreased ... concerning the sensing and repair of DNA damage under experimental conditions of acute ...

They investigated a form of apoptosis caused by hydroxy radicals formed in the ... that treating cells directly with hydrogen peroxide caused DNA damage responses and growth arrest, but the cells didn ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

Unlike the well-known DNA damage response, RSR is triggered when ... a fiery and inflammatory form of cell death, and apoptosis, a quieter, programmed cell death. In both cases, ZAK-alpha was ...

At this point, DNA repair systems recognize it as DNA damage and trigger a form of permanent cell cycle arrest called replicative senescence, which may lead to cell death called apoptosis. 5 This ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

"Sunburn damages the DNA, leading to cell death and inflammation. So the textbooks say. But in this study we were surprised to learn that this is a result of damage to the RNA, not the DNA that ...

Most dividing cells in the body have well-defined checkpoint mechanisms to sense and correct DNA damage during DNA replication. Neurons, however, do not divide. For this reason, they are at ...