Previous studies have mapped out the cytoplasmic cGAS-STING pathway in the cytoplasm, known for responding to foreign nucleic acids. The Fusion Visualization system 2 cell line was developed to ...

Telomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This ...

While short bursts of STING-mediated inflammation are crucial, in some people this pathway is chronically "on," a state that has been linked with neurodegeneration and other diseases of aging, as ...

Its central role in immunosurveillance positions the cGAS-STING pathway as an attractive anti-cancer immunotherapeutic drug target for chemical agonists or vaccine adjuvants and suggests a key ...

One such pathway includes the stimulator of interferon genes (STING) pathway which acts as a mediator of inflammation in the context of cell stress and tissue damage. This pathway is activated through ...

STING (stimulator of interferon genes) is a key mediator of innate immunity and the STING pathway has been shown to be involved in the induction of an anti-tumor immune response. We recently spoke to ...

The findings show that when activated, the STING pathway triggers a natural immune response against the tumor. This includes production of chemical signals that help the immune system identify ...

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

STING (stimulator of interferon genes) is a key mediator of innate immunity and the STING pathway has been shown to be involved in the induction of an anti-tumor immune response. We recently spoke to ...

Double-edged STING: Study identifies new pathway involved in aging Date: September 20, 2024 Source: University of Pittsburgh Summary: A protein called STING, previously shown to control a pathway ...