Dual mechanisms found to guard mitochondria against fusion-related damage
Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...
The EMBO Journal15d
Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs
However, beyond the interaction of Roq1 R22 and the Ubr1 type-1 site, the molecular mechanism of this unusual regulation ... with Roq1(4A) or a RA dipeptide, which lack the hydrophobic motif but can ...
C&EN19d
Insights into Dermal Permeation of Skin Oil Oxidation Products from Enhanced Sampling Molecular Dynamics Simulation
Here, we employ atomistic molecular dynamics simulations to study the translocation ... We identify the high degree of order and stochastic, long-lived temporal asymmetries in the membrane structure ...
C&EN24d
Recalibrating Protection Factors Using Millisecond Hydrogen/Deuterium Exchange Mass Spectrometry
School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, U.K. School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, U ...