This can cause blood to back up in the veins and cause symptoms like swelling and nausea. Left-sided heart failure usually occurs first. Right-sided heart failure is typically a result of left ...

Symptoms and signs of heart failure, a left ventricular ejection fraction of 50% or greater, and evidence of cardiac structural abnormalities at rest or with exercise are required for the diagnosis.

Because of the potential for fluid retention and worsening edema, clinical studies have excluded patients with New York Heart Association (NYHA) functional class III or IV heart failure.

Swollen feet and ankles are one of the common signs of heart failure. This swelling often points to right-sided heart failure. Get medical attention right away if you develop heart failure symptoms.

Unfortunately, concerns of weight gain, edema, and the potential to exacerbate or precipitate heart failure may limit the use of TZDs, especially in heart failure patients.