Nutrient excess triggers profound functional changes in the hypothalamus, a critical brain site that mediates metabolic control throughout the body. For example, excess calorie intake provokes ...

"In obese patients, adipose tissue secretes excessive leptin, which triggers the chronic action of melanocortin. Our study ...

By understanding how spexin influences leptin action, researchers hope to develop strategies to combat obesity and related metabolic disorders[3]. Moreover, spexin has been identified as a ...

For this purpose, we aimed to investigate whether CLK2 is expressed in the hypothalamic nuclei and whether hypothalamic CLK2 is part of insulin and leptin signaling and action. We also aimed to ...