Instead, the researchers used a leukemia mouse model with a defective genetic proofreading system called Polg, which gradually accrues mtDNA mutations. By disrupting Polg's proofreading function ...

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, with disease progression ranging from slow and indolent to aggressive ...

These engineered cells were resistant to fratricide and displayed potent antitumor activity both in culture and in a xenograft mouse model of T cell acute lymphoblastic leukemia (T-ALL). CAR T ...

Instead, the researchers used a leukemia mouse model with a defective genetic proofreading system called Polg, which gradually accrues mtDNA mutations. By disrupting Polg’s proofreading function in ...

A total of 1500 unfractionated bone marrow cells from a UbC6-Luc transgenic mouse, together with 1.2 ... CO, USA). For leukemia immunophenotyping, cells isolated from spleen and bone marrow ...