This valuable study reports on the critical role of ANKRD5 (ANKEF1) in sperm motility and male fertility. However, the supporting data remain incomplete. This work will be of interest to biomedical ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

The table below is a review of notable updates that occurred in January 2025 for investigational products in development.

coli infection resulted in reduced mitochondrial activity in skeletal muscles ... Next, his team plans to design and conduct clinical trials to test the effect of IL-6 antibodies, which are already ...

Stem cell and proteostatic dysfunction, telomere erosion, DNA damage, mitochondrial dysfunction ... Such enzymes could be ...

Interestingly, transgenic mice that expressed HCV core, E1, E2 and NS2 proteins were resistant to Fas antibody-stimulated ... as apoptosis assays in vivo. Mitochondrial apoptotic signalling ...

Conclusion: HSFs showed increased mitochondrial priming with higher level of proapoptotic activator BIM and were primed to death. ABT-263 showed great therapeutic ability in the treatment of ...

VDAC1 interacting with Rab7a at mitochondria-lysosome contact site interfered with ... followed by intracellular staining with primary antibodies against Tom20 (CST, Danvers, US) and LAMP2 (Thermo ...

BACKGROUND: Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells.

Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how mitochondria influence the body's immune response through modulating specific cell signaling ...

Mitochondria organelles came from primordial bacterial endosymbionts and still preserve distinct genes for important functions like making ATP. To speed the emerging therapeutic research into the ...