Animal models, particularly those that resemble human age-related physiological changes, are needed to better understand immunosenescence and to improve health outcomes. Here, we explore the utility ...

In recognising this UK Sport’s approach to funding reflects that journey and works on the basis of an athlete pathway with three clear and distinct levels that make up the World Class Pathway. The two ...

More than three years after the Pathways Alliance oilsands group first announced plans for a proposed $16.5-billion carbon capture network in northern Alberta, the consortium still hasn’t given ...

Rachubinski and colleagues provide an important manuscript that includes two major advances in understanding immune dysregulation in a large cohort of individuals with Down syndrome. The work ...

This review explores the crosstalk between cellular metabolic pathways including glycolysis, oxidative phosphorylation, fatty acid metabolism, and the immune processes that govern cardiac aging. With ...

Figure 1. ER stress and activation of the UPR signaling pathways. The UPR is triggered by ER stress sensors, namely IRE1, PERK, and ATF6 upon UPR target genes related dissociation of BiP. The ...

Mainstreaming the below protection principles listed in no particular order of importance will allow to maximize the protection impact of complementary pathways. Complementary pathways help enhance ...

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