Scientists Conducted Experiments on Worms and Discovered a Switch to Control Aging Worms have provided scientists with a ...

TFEB/TFE3 links autophagy and lysosomal biogenesis through the transcriptional activation of genes involved in autophagosome biogenesis and autophagy-lysosomal fusion.

Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB ...

Moreover, we demonstrated that TFEB directed the trophoblast syncytialization response driven by mTOR complex 1 (mTORC1) signaling. TFEB expression positively correlated with the reinforced ...

Coave Therapeutics is delighted to announce that it is one of six organisations sharing $2.9 million in grants from the ALS Association that support the advancement of novel therapies for the ...

Vienna researchers reported that 7 of 10 patients treated with systemic sirolimus had noted improvements in skin lesions, which continued for up to 2 years of follow-up.

As TFEB nuclear translocation is mTOR-dependent (Settembre et al, 2012a), we investigated whether TFEB mitochondrial localization also shows mTOR regulation. Inhibition of mTOR using torin-1 in HeLa ...

Egyptian auto parts marketplace Mtor announces a $2.8M pre-seed round led by Algebra Ventures, with participation from Dutch Founders Fund.

Single-cell data on cell signaling responses to nutrient variation enable quantitative models of cellular control over protein synthesis, formalizing the concept of mTOR as a homeostatic controller of ...

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.